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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models
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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models Paperback - 2007 - 1st Edition

by Charles J. Epstein


From the publisher

This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.

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  • Title The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models
  • Author Charles J. Epstein
  • Binding Paperback
  • Edition number 1st
  • Edition 1
  • Pages 512
  • Volumes 1
  • Language ENG
  • Publisher Cambridge University Press
  • Date 2007-07-26
  • ISBN 9780521038096 / 052103809X
  • Weight 1.56 lbs (0.71 kg)
  • Dimensions 9.21 x 6.14 x 1.03 in (23.39 x 15.60 x 2.62 cm)
  • Dewey Decimal Code 616.042
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THE CONSEQUENCES OF CHROMOSOME IMBALANCE
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THE CONSEQUENCES OF CHROMOSOME IMBALANCE

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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models
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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

by Charles J. Epstein

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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

by Charles J. Epstein

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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models (Developmental and...
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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models (Developmental and Cell Biology Series, Series Number 18)

by Epstein, Charles J

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